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2jex

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[[Image:2jex.jpg|left|200px]]
[[Image:2jex.jpg|left|200px]]
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{{Structure
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{{STRUCTURE_2jex| PDB=2jex | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jex OCA], [http://www.ebi.ac.uk/pdbsum/2jex PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jex RCSB]</span>
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'''TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION'''
'''TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION'''
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[[Category: Seavers, P R.]]
[[Category: Seavers, P R.]]
[[Category: Sizov, D.]]
[[Category: Sizov, D.]]
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[[Category: activator]]
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[[Category: Activator]]
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[[Category: bovine papillomavirus]]
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[[Category: Bovine papillomavirus]]
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[[Category: dna replication]]
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[[Category: Dna replication]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: e1]]
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[[Category: E1]]
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[[Category: e2]]
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[[Category: E2]]
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[[Category: early protein]]
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[[Category: Early protein]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: oxidation]]
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[[Category: Oxidation]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: redox control]]
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[[Category: Redox control]]
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[[Category: replication initiation]]
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[[Category: Replication initiation]]
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[[Category: repressor]]
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[[Category: Repressor]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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[[Category: viral transcription factor]]
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[[Category: Viral transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:48:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:57:11 2008''
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Revision as of 05:48, 4 May 2008

Image:2jex.jpg

Template:STRUCTURE 2jex

TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION


Overview

Redox changes are one of the factors that influence cell-cycle progression and that control the processes of cellular proliferation, differentiation, senescence and apoptosis. Proteins regulated through redox-sensitive cysteines have been characterized but specific 'sulphydryl switches' in replication proteins remain to be identified. In bovine papillomavirus type-1, DNA replication begins when the viral transcription factor E2 recruits the viral initiator protein E1 to the origin of DNA replication (ori). Here we show that a novel dimerization interface in the E2 transcription activation domain is stabilized by a disulphide bond. Oxidative cross-linking via Cys57 sequesters the interaction surface between E1 and E2, preventing pre-initiation and replication initiation complex formation. Our data demonstrate that as well as a mechanism for regulating DNA binding, redox reactions can control replication by modulating the tertiary structure of critical protein factors using a specific redox sensor.

About this Structure

2JEX is a Single protein structure of sequence from Bovine papillomavirus type 1. Full crystallographic information is available from OCA.

Reference

Transcription activator structure reveals redox control of a replication initiation reaction., Sanders CM, Sizov D, Seavers PR, Ortiz-Lombardia M, Antson AA, Nucleic Acids Res. 2007;35(10):3504-15. Epub 2007 May 3. PMID:17478495 Page seeded by OCA on Sun May 4 08:48:25 2008

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