2jgo
From Proteopedia
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[[Image:2jgo.jpg|left|200px]] | [[Image:2jgo.jpg|left|200px]] | ||
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'''STUCTURE OF THE ARSENATED DE NOVO DESIGNED PEPTIDE COIL SER L9C''' | '''STUCTURE OF THE ARSENATED DE NOVO DESIGNED PEPTIDE COIL SER L9C''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2JGO is a [[Single protein]] structure | + | 2JGO is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Stuckey, J A.]] | [[Category: Stuckey, J A.]] | ||
[[Category: Touw, D S.]] | [[Category: Touw, D S.]] | ||
| - | [[Category: | + | [[Category: De novo design]] |
| - | + | [[Category: De novo protein]] | |
| - | [[Category: | + | [[Category: Three-stranded coiled coil]] |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:53:15 2008'' |
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Revision as of 05:53, 4 May 2008
STUCTURE OF THE ARSENATED DE NOVO DESIGNED PEPTIDE COIL SER L9C
Overview
Arsenic, a contaminant of water supplies worldwide, is one of the most toxic inorganic ions. Despite arsenic's health impact, there is relatively little structural detail known about its interactions with proteins. Bacteria such as Escherichia coli have evolved arsenic resistance using the Ars operon that is regulated by ArsR, a repressor protein that dissociates from DNA when As(III) binds. This protein undergoes a critical conformational change upon binding As(III) with three cysteine residues. Unfortunately, structures of ArsR with or without As(III) have not been reported. Alternatively, de novo designed peptides can bind As(III) in an endo configuration within a thiolate-rich environment consistent with that proposed for both ArsR and ArsD. We report the structure of the As(III) complex of Coil Ser L9C to a 1.8-A resolution, providing x-ray characterization of As(III) in a Tris thiolate protein environment and allowing a structural basis by which to understand arsenated ArsR.
About this Structure
2JGO is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils., Touw DS, Nordman CE, Stuckey JA, Pecoraro VL, Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11969-74. Epub 2007 Jul 3. PMID:17609383 Page seeded by OCA on Sun May 4 08:53:15 2008
