2noq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2noq.gif|left|200px]]
[[Image:2noq.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2noq |SIZE=350|CAPTION= <scene name='initialview01'>2noq</scene>
+
The line below this paragraph, containing "STRUCTURE_2noq", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2noq| PDB=2noq | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2noq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2noq OCA], [http://www.ebi.ac.uk/pdbsum/2noq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2noq RCSB]</span>
+
-
}}
+
'''Structure of ribosome-bound cricket paralysis virus IRES RNA'''
'''Structure of ribosome-bound cricket paralysis virus IRES RNA'''
Line 35: Line 32:
[[Category: Spahn, C M.T.]]
[[Category: Spahn, C M.T.]]
[[Category: Westhof, E.]]
[[Category: Westhof, E.]]
-
[[Category: internal initiation]]
+
[[Category: Internal initiation]]
-
[[Category: ires rna]]
+
[[Category: Ires rna]]
-
[[Category: ribosome]]
+
[[Category: Ribosome]]
-
[[Category: translation]]
+
[[Category: Translation]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:42:57 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:06:06 2008''
+

Revision as of 06:42, 4 May 2008

Image:2noq.gif

Template:STRUCTURE 2noq

Structure of ribosome-bound cricket paralysis virus IRES RNA


Overview

Internal ribosome entry sites (IRESs) facilitate an alternative, end-independent pathway of translation initiation. A particular family of dicistroviral IRESs can assemble elongation-competent 80S ribosomal complexes in the absence of canonical initiation factors and initiator transfer RNA. We present here a cryo-EM reconstruction of a dicistroviral IRES bound to the 80S ribosome. The resolution of the cryo-EM reconstruction, in the subnanometer range, allowed the molecular structure of the complete IRES in its active, ribosome-bound state to be solved. The structure, harboring three pseudoknot-containing domains, each with a specific functional role, shows how defined elements of the IRES emerge from a compactly folded core and interact with the key ribosomal components that form the A, P and E sites, where tRNAs normally bind. Our results exemplify the molecular strategy for recruitment of an IRES and reveal the dynamic features necessary for internal initiation.

About this Structure

2NOQ is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the ribosome-bound cricket paralysis virus IRES RNA., Schuler M, Connell SR, Lescoute A, Giesebrecht J, Dabrowski M, Schroeer B, Mielke T, Penczek PA, Westhof E, Spahn CM, Nat Struct Mol Biol. 2006 Dec;13(12):1092-6. Epub 2006 Nov 19. PMID:17115051 Page seeded by OCA on Sun May 4 09:42:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2noq"
Personal tools