2oct
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2oct.gif|left|200px]] | [[Image:2oct.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2oct", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_2oct| PDB=2oct | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''Stefin B (Cystatin B) tetramer''' | '''Stefin B (Cystatin B) tetramer''' | ||
| Line 31: | Line 28: | ||
[[Category: Kokalj, S Jenko.]] | [[Category: Kokalj, S Jenko.]] | ||
[[Category: Turk, D.]] | [[Category: Turk, D.]] | ||
| - | [[Category: | + | [[Category: Amyloid]] |
| - | [[Category: | + | [[Category: Cystatin]] |
| - | [[Category: | + | [[Category: Domain-swapping]] |
| - | [[Category: | + | [[Category: Hand shaking]] |
| - | [[Category: | + | [[Category: Proline isomerization]] |
| - | [[Category: | + | [[Category: Stefin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:37:42 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:37, 4 May 2008
Stefin B (Cystatin B) tetramer
Contents |
Overview
Here we present the tetrameric structure of stefin B, which is the result of a process by which two domain-swapped dimers of stefin B are transformed into tetramers. The transformation involves a previously unidentified process of extensive intermolecular contacts, termed hand shaking, which occurs concurrently with trans to cis isomerization of proline 74. This proline residue is widely conserved throughout the cystatin superfamily, a member of which, human cystatin C, is the key protein in cerebral amyloid angiopathy. These results are consistent with the hypothesis that isomerization of proline residues can play a decisive role in amyloidogenesis.
Disease
Known disease associated with this structure: Epilepsy, progressive myoclonic 1 OMIM:[601145]
About this Structure
2OCT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Essential role of proline isomerization in stefin B tetramer formation., Jenko Kokalj S, Guncar G, Stern I, Morgan G, Rabzelj S, Kenig M, Staniforth RA, Waltho JP, Zerovnik E, Turk D, J Mol Biol. 2007 Mar 9;366(5):1569-79. Epub 2006 Dec 16. PMID:17217964 Page seeded by OCA on Sun May 4 10:37:42 2008
