2pid

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[[Image:2pid.jpg|left|200px]]
[[Image:2pid.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2pid |SIZE=350|CAPTION= <scene name='initialview01'>2pid</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_2pid", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=YSA:5&#39;-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE'>YSA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= YARS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2pid| PDB=2pid | SCENE= }}
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|RELATEDENTRY=[[1vbm|1vbm]], [[3ts1|3ts1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pid OCA], [http://www.ebi.ac.uk/pdbsum/2pid PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pid RCSB]</span>
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}}
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'''Crystal structure of human mitochondrial tyrosyl-tRNA synthetase in complex with an adenylate analog'''
'''Crystal structure of human mitochondrial tyrosyl-tRNA synthetase in complex with an adenylate analog'''
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[[Category: Sauter, C.]]
[[Category: Sauter, C.]]
[[Category: Touze, E.]]
[[Category: Touze, E.]]
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[[Category: aminoacyl-trna synthetase]]
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[[Category: Aminoacyl-trna synthetase]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: ligase]]
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[[Category: Ligase]]
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[[Category: mitochondrion]]
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[[Category: Mitochondrion]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: protein biosynthesis,]]
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[[Category: Protein biosynthesis]]
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[[Category: protein-substrate complex]]
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[[Category: Protein-substrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:10:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:36:17 2008''
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Revision as of 10:10, 4 May 2008

Image:2pid.jpg

Template:STRUCTURE 2pid

Crystal structure of human mitochondrial tyrosyl-tRNA synthetase in complex with an adenylate analog


Overview

We report the structure of a strictly mitochondrial human synthetase, namely tyrosyl-tRNA synthetase (mt-TyrRS), in complex with an adenylate analog at 2.2 A resolution. The structure is that of an active enzyme deprived of the C-terminal S4-like domain and resembles eubacterial TyrRSs with a canonical tyrosine-binding pocket and adenylate-binding residues typical of class I synthetases. Two bulges at the enzyme surface, not seen in eubacterial TyrRSs, correspond to conserved sequences in mt-TyrRSs. The synthetase electrostatic surface potential differs from that of other TyrRSs, including the human cytoplasmic homolog and the mitochondrial one from Neurospora crassa. The homodimeric human mt-TyrRS shows an asymmetry propagating from the dimer interface toward the two catalytic sites and extremities of each subunit. Mutagenesis of the catalytic domain reveals functional importance of Ser200 in line with an involvement of A73 rather than N1-N72 in tyrosine identity.

About this Structure

2PID is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human mitochondrial tyrosyl-tRNA synthetase reveals common and idiosyncratic features., Bonnefond L, Frugier M, Touze E, Lorber B, Florentz C, Giege R, Sauter C, Rudinger-Thirion J, Structure. 2007 Nov;15(11):1505-16. PMID:17997975 Page seeded by OCA on Sun May 4 13:10:07 2008

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OCA

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