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2qr8

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[[Image:2qr8.jpg|left|200px]]
[[Image:2qr8.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2qr8 |SIZE=350|CAPTION= <scene name='initialview01'>2qr8</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2qr8", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Rps6ka3, Rps6ka-rs1, Rsk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_2qr8| PDB=2qr8 | SCENE= }}
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|RELATEDENTRY=[[2qr7|2QR7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qr8 OCA], [http://www.ebi.ac.uk/pdbsum/2qr8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qr8 RCSB]</span>
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}}
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'''2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)'''
'''2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)'''
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[[Category: Malakhova, M.]]
[[Category: Malakhova, M.]]
[[Category: Tereshko, V.]]
[[Category: Tereshko, V.]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: autoinhibitory]]
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[[Category: Autoinhibitory]]
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[[Category: kinase domain]]
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[[Category: Kinase domain]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: rsk2]]
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[[Category: Rsk2]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:28:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:52:26 2008''
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Revision as of 12:28, 4 May 2008

Image:2qr8.jpg

Template:STRUCTURE 2qr8

2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)


Overview

The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.

About this Structure

2QR8 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2., Malakhova M, Tereshko V, Lee SY, Yao K, Cho YY, Bode A, Dong Z, Nat Struct Mol Biol. 2008 Jan;15(1):112-3. Epub 2007 Dec 16. PMID:18084304 Page seeded by OCA on Sun May 4 15:28:01 2008

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