2srt

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[[Image:2srt.gif|left|200px]]
[[Image:2srt.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2srt |SIZE=350|CAPTION= <scene name='initialview01'>2srt</scene>
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The line below this paragraph, containing "STRUCTURE_2srt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=INH:N-(R-CARBOXY-ETHYL)-ALPHA-(S)-(2-PHENYLETHYL)GLYCYL-L-ARGININE-N-PHENYLAMIDE'>INH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HUMAN STROMELYSIN-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2srt| PDB=2srt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2srt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2srt OCA], [http://www.ebi.ac.uk/pdbsum/2srt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2srt RCSB]</span>
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}}
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'''CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT PH 5.5 AND 40OC COMPLEXED WITH INHIBITOR'''
'''CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT PH 5.5 AND 40OC COMPLEXED WITH INHIBITOR'''
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==About this Structure==
==About this Structure==
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2SRT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1SRT. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SRT OCA].
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2SRT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1srt 1srt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SRT OCA].
==Reference==
==Reference==
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[[Category: Connell, J F.O.]]
[[Category: Connell, J F.O.]]
[[Category: Gooley, P R.]]
[[Category: Gooley, P R.]]
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[[Category: metzincin]]
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[[Category: Metzincin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:21:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:03:22 2008''
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Revision as of 14:21, 4 May 2008

Image:2srt.gif

Template:STRUCTURE 2srt

CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT PH 5.5 AND 40OC COMPLEXED WITH INHIBITOR


Overview

The three-dimensional structure of the catalytic domain of stromelysin-1 complexed with an N-carboxyl alkyl inhibitor has been determined by NMR methods. The global fold consists of three helices, a five stranded beta-sheet and a methionine located in a turn near the catalytic histidines, classifying stromelysin-1 as a metzincin. Stromelysin-1 is unique in having two independent zinc binding sites: a catalytic site and a structural site. The inhibitor binds in an extended conformation. The S1' subsite is a deep hydrophobic pocket, whereas S2' appears shallow and S3' open.

About this Structure

2SRT is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1srt. Full crystallographic information is available from OCA.

Reference

The NMR structure of the inhibited catalytic domain of human stromelysin-1., Gooley PR, O'Connell JF, Marcy AI, Cuca GC, Salowe SP, Bush BL, Hermes JD, Esser CK, Hagmann WK, Springer JP, et al., Nat Struct Biol. 1994 Feb;1(2):111-8. PMID:7656014 Page seeded by OCA on Sun May 4 17:21:26 2008

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