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2zta
From Proteopedia
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[[Image:2zta.gif|left|200px]] | [[Image:2zta.gif|left|200px]] | ||
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'''X-RAY STRUCTURE OF THE GCN4 LEUCINE ZIPPER, A TWO-STRANDED, PARALLEL COILED COIL''' | '''X-RAY STRUCTURE OF THE GCN4 LEUCINE ZIPPER, A TWO-STRANDED, PARALLEL COILED COIL''' | ||
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[[Category: Klemm, J D.]] | [[Category: Klemm, J D.]] | ||
[[Category: Shea, E K.O.]] | [[Category: Shea, E K.O.]] | ||
| - | [[Category: | + | [[Category: Leucine zipper]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:14:27 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:14, 4 May 2008
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| 2zta, resolution 1.80Å () | |||||||
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| Non-Standard Residues: | |||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-RAY STRUCTURE OF THE GCN4 LEUCINE ZIPPER, A TWO-STRANDED, PARALLEL COILED COIL
Overview
The x-ray crystal structure of a peptide corresponding to the leucine zipper of the yeast transcriptional activator GCN4 has been determined at 1.8 angstrom resolution. The peptide forms a parallel, two-stranded coiled coil of alpha helices packed as in the "knobs-into-holes" model proposed by Crick in 1953. Contacts between the helices include ion pairs and an extensive hydrophobic interface that contains a distinctive hydrogen bond. The conserved leucines, like the residues in the alternate hydrophobic repeat, make side-to-side interactions (as in a handshake) in every other layer of the dimer interface. The crystal structure of the GCN4 leucine zipper suggests a key role for the leucine repeat, but also shows how other features of the coiled coil contribute to dimer formation.
About this Structure
2ZTA is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 2ZTA with [Designer Proteins]. Full crystallographic information is available from OCA.
Reference
X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil., O'Shea EK, Klemm JD, Kim PS, Alber T, Science. 1991 Oct 25;254(5031):539-44. PMID:1948029 Page seeded by OCA on Sun May 4 20:14:27 2008
