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3bwu

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[[Image:3bwu.jpg|left|200px]]
[[Image:3bwu.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3bwu |SIZE=350|CAPTION= <scene name='initialview01'>3bwu</scene>, resolution 1.760&Aring;
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The line below this paragraph, containing "STRUCTURE_3bwu", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Edo+Binding+Site+For+Residue+D+126'>AC1</scene>, <scene name='pdbsite=AC2:Edo+Binding+Site+For+Residue+C+206'>AC2</scene>, <scene name='pdbsite=AC3:Edo+Binding+Site+For+Residue+C+207'>AC3</scene>, <scene name='pdbsite=AC4:Edo+Binding+Site+For+Residue+C+208'>AC4</scene>, <scene name='pdbsite=AC5:Edo+Binding+Site+For+Residue+F+5'>AC5</scene>, <scene name='pdbsite=AC6:Edo+Binding+Site+For+Residue+C+209'>AC6</scene>, <scene name='pdbsite=AC7:Edo+Binding+Site+For+Residue+C+210'>AC7</scene>, <scene name='pdbsite=AC8:Edo+Binding+Site+For+Residue+C+211'>AC8</scene>, <scene name='pdbsite=AC9:Edo+Binding+Site+For+Residue+F+9'>AC9</scene>, <scene name='pdbsite=BC1:Edo+Binding+Site+For+Residue+C+212'>BC1</scene>, <scene name='pdbsite=BC2:Edo+Binding+Site+For+Residue+D+127'>BC2</scene>, <scene name='pdbsite=BC3:Edo+Binding+Site+For+Residue+C+213'>BC3</scene>, <scene name='pdbsite=BC4:Edo+Binding+Site+For+Residue+F+155'>BC4</scene> and <scene name='pdbsite=BC5:Peg+Binding+Site+For+Residue+C+214'>BC5</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= fimC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), fimD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), fimF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_3bwu| PDB=3bwu | SCENE= }}
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|RELATEDENTRY=[[1ze3|1ZE3]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bwu OCA], [http://www.ebi.ac.uk/pdbsum/3bwu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bwu RCSB]</span>
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}}
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'''Crystal structure of the ternary complex of FimD (N-Terminal Domain, FimDN) with FimC and the N-terminally truncated pilus subunit FimF (FimFt)'''
'''Crystal structure of the ternary complex of FimD (N-Terminal Domain, FimDN) with FimC and the N-terminally truncated pilus subunit FimF (FimFt)'''
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[[Category: Eidam, O.]]
[[Category: Eidam, O.]]
[[Category: Grutter, M G.]]
[[Category: Grutter, M G.]]
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[[Category: chaperone]]
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[[Category: Chaperone]]
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[[Category: mebrane protein]]
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[[Category: Mebrane protein]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: n-terminal domain]]
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[[Category: N-terminal domain]]
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[[Category: structural]]
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[[Category: Structural]]
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[[Category: structural protein]]
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[[Category: Structural protein]]
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[[Category: ternary complex with chaperone and pilus subunit]]
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[[Category: Ternary complex with chaperone and pilus subunit]]
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[[Category: usher]]
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[[Category: Usher]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:10:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:29:25 2008''
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Revision as of 18:10, 4 May 2008

Image:3bwu.jpg

Template:STRUCTURE 3bwu

Crystal structure of the ternary complex of FimD (N-Terminal Domain, FimDN) with FimC and the N-terminally truncated pilus subunit FimF (FimFt)


Overview

Type 1 pili, anchored to the outer membrane protein FimD, enable uropathogenic Escherichia coli to attach to host cells. During pilus biogenesis, the N-terminal periplasmic domain of FimD (FimD(N)) binds complexes between the chaperone FimC and pilus subunits via its partly disordered N-terminal segment, as recently shown for the FimC-FimH(P)-FimD(N) ternary complex. We report the structure of a new ternary complex (FimC-FimF(t)-FimD(N)) with the subunit FimF(t) instead of FimH(p). FimD(N) recognizes FimC-FimF(t) and FimC-FimH(P) very similarly, predominantly through hydrophobic interactions. The conserved binding mode at a "hot spot" on the chaperone surface could guide the design of pilus assembly inhibitors.

About this Structure

3BWU is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD., Eidam O, Dworkowski FS, Glockshuber R, Grutter MG, Capitani G, FEBS Lett. 2008 Mar 5;582(5):651-5. Epub 2008 Jan 31. PMID:18242189 Page seeded by OCA on Sun May 4 21:10:40 2008

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