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2eue

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==Overview==
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{{ABSTRACT_16236260}}
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AMP-activated protein kinase (AMPK) is a master metabolic regulator, and is an important target for drug development against diabetes, obesity, and other diseases. AMPK is a hetero-trimeric enzyme, with a catalytic (alpha) subunit, and two regulatory (beta and gamma) subunits. Here we report the crystal structure at 2.2A resolution of the protein kinase domain (KD) of the catalytic subunit of yeast AMPK (commonly known as SNF1). The Snf1-KD structure shares strong similarity to other protein kinases, with a small N-terminal lobe and a large C-terminal lobe. Two negative surface patches in the structure may be important for the recognition of the substrates of this kinase.
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==About this Structure==
==About this Structure==
2EUE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EUE OCA].
2EUE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EUE OCA].
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==Reference==
 
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Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1., Rudolph MJ, Amodeo GA, Bai Y, Tong L, Biochem Biophys Res Commun. 2005 Dec 2;337(4):1224-8. Epub 2005 Oct 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16236260 16236260]
 
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Tong, L.]]
[[Category: Tong, L.]]
[[Category: Kinase domain]]
[[Category: Kinase domain]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 25 15:05:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 25 18:38:02 2008''

Revision as of 15:38, 25 June 2008

Image:2eue.png

Template:STRUCTURE 2eue

Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1


Template:ABSTRACT 16236260

About this Structure

2EUE is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Page seeded by OCA on Wed Jun 25 18:38:02 2008

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