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1g72

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[[Image:1g72.jpg|left|200px]]
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[[Image:1g72.png|left|200px]]
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==Overview==
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{{ABSTRACT_11149955}}
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The catalytic mechanism of the reductive half reaction of the quinoprotein methanol dehydrogenase (MDH) is believed to proceed either through a hemiketal intermediate or by direct transfer of a hydride ion from the substrate methyl group to the cofactor, pyrroloquinoline quinone (PQQ). A crystal structure of the enzyme-substrate complex of a similar quinoprotein, glucose dehydrogenase, has recently been reported that strongly favors the hydride transfer mechanism in that enzyme. A theoretical analysis and an improved refinement of the 1.9-A resolution crystal structure of MDH from Methylophilus methylotrophus W3A1 in the presence of methanol, reported earlier, indicates that the observed tetrahedral configuration of the C-5 atom of PQQ in that study represents the C-5-reduced form of the cofactor and lends support for a hydride transfer mechanism for MDH.
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==About this Structure==
==About this Structure==
1G72 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1b2n 1b2n]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G72 OCA].
1G72 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1b2n 1b2n]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G72 OCA].
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==Reference==
 
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Catalytic mechanism of quinoprotein methanol dehydrogenase: A theoretical and x-ray crystallographic investigation., Zheng YJ, Xia Zx, Chen Zw, Mathews FS, Bruice TC, Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):432-4. Epub 2001 Jan 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11149955 11149955]
 
[[Category: Methylophilus methylotrophus]]
[[Category: Methylophilus methylotrophus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Zheng, Y.]]
[[Category: Zheng, Y.]]
[[Category: Quinoprotein]]
[[Category: Quinoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:13:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 25 19:14:58 2008''

Revision as of 16:14, 25 June 2008

Image:1g72.png

Template:STRUCTURE 1g72

CATALYTIC MECHANISM OF QUINOPROTEIN METHANOL DEHYDROGENASE: A THEORETICAL AND X-RAY CRYSTALLOGRAPHIC INVESTIGATION


Template:ABSTRACT 11149955

About this Structure

1G72 is a Protein complex structure of sequences from Methylophilus methylotrophus. This structure supersedes the now removed PDB entry 1b2n. Full crystallographic information is available from OCA.

Page seeded by OCA on Wed Jun 25 19:14:58 2008

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