1cx8

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[[Image:1cx8.gif|left|200px]]
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[[Image:1cx8.png|left|200px]]
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==Overview==
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{{ABSTRACT_10531064}}
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The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome. The crystal structure of the dimeric ectodomain of the human TfR, determined here to 3.2 angstroms resolution, reveals a three-domain subunit. One domain closely resembles carboxy- and aminopeptidases, and features of membrane glutamate carboxypeptidase can be deduced from the TfR structure. A model is proposed for Tf binding to the receptor.
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==About this Structure==
==About this Structure==
1CX8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1CX8 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb35_1.html Ferritin and Transferrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX8 OCA].
1CX8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1CX8 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb35_1.html Ferritin and Transferrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX8 OCA].
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==Reference==
 
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Crystal structure of the ectodomain of human transferrin receptor., Lawrence CM, Ray S, Babyonyshev M, Galluser R, Borhani DW, Harrison SC, Science. 1999 Oct 22;286(5440):779-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10531064 10531064]
 
[[Category: Ferritin and Transferrin]]
[[Category: Ferritin and Transferrin]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ray, S.]]
[[Category: Ray, S.]]
[[Category: Human transferrin receptor]]
[[Category: Human transferrin receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:12:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:09:24 2008''

Revision as of 14:09, 26 June 2008

Image:1cx8.png

Template:STRUCTURE 1cx8

CRYTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR


Template:ABSTRACT 10531064

About this Structure

1CX8 is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1CX8 with [Ferritin and Transferrin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:09:24 2008

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