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1dkz

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[[Image:1dkz.gif|left|200px]]
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[[Image:1dkz.png|left|200px]]
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==Overview==
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{{ABSTRACT_8658133}}
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DnaK and other members of the 70-kilodalton heat-shock protein (hsp70) family promote protein folding, interaction, and translocation, both constitutively and in response to stress, by binding to unfolded polypeptide segments. These proteins have two functional units: a substrate-binding portion binds the polypeptide, and an adenosine triphosphatase portion facilitates substrate exchange. The crystal structure of a peptide complex with the substrate-binding unit of DnaK has now been determined at 2.0 angstroms resolution. The structure consists of a beta-sandwich subdomain followed by alpha-helical segments. The peptide is bound to DnaK in an extended conformation through a channel defined by loops from the beta sandwich. An alpha-helical domain stabilizes the complex, but does not contact the peptide directly. This domain is rotated in the molecules of a second crystal lattice, which suggests a model of conformation-dependent substrate binding that features a latch mechanism for maintaining long lifetime complexes.
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==About this Structure==
==About this Structure==
1DKZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The following page contains interesting information on the relation of 1DKZ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb32_1.html Chaperones]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DKZ OCA].
1DKZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The following page contains interesting information on the relation of 1DKZ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb32_1.html Chaperones]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DKZ OCA].
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==Reference==
 
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Structural analysis of substrate binding by the molecular chaperone DnaK., Zhu X, Zhao X, Burkholder WF, Gragerov A, Ogata CM, Gottesman ME, Hendrickson WA, Science. 1996 Jun 14;272(5268):1606-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8658133 8658133]
 
[[Category: Chaperones]]
[[Category: Chaperones]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Zhu, X.]]
[[Category: Zhu, X.]]
[[Category: Dnak]]
[[Category: Dnak]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:58:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:11:00 2008''

Revision as of 14:11, 26 June 2008

Image:1dkz.png

Template:STRUCTURE 1dkz

THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 NATIVE CRYSTALS


Template:ABSTRACT 8658133

About this Structure

1DKZ is a Single protein structure of sequence from Escherichia coli. The following page contains interesting information on the relation of 1DKZ with [Chaperones]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:11:00 2008

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