This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1fxk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fxk.jpg|left|200px]]
+
[[Image:1fxk.png|left|200px]]
<!--
<!--
Line 12: Line 12:
-
==Overview==
+
{{ABSTRACT_11106732}}
-
Prefoldin (GimC) is a hexameric molecular chaperone complex built from two related classes of subunits and present in all eukaryotes and archaea. Prefoldin interacts with nascent polypeptide chains and, in vitro, can functionally substitute for the Hsp70 chaperone system in stabilizing non-native proteins for subsequent folding in the central cavity of a chaperonin. Here, we present the crystal structure and characterization of the prefoldin hexamer from the archaeum Methanobacterium thermoautotrophicum. Prefoldin has the appearance of a jellyfish: its body consists of a double beta barrel assembly with six long tentacle-like coiled coils protruding from it. The distal regions of the coiled coils expose hydrophobic patches and are required for multivalent binding of nonnative proteins.
+
==About this Structure==
==About this Structure==
The following page contains interesting information on the relation of 1FXK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb32_1.html Chaperones]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FXK OCA].
The following page contains interesting information on the relation of 1FXK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb32_1.html Chaperones]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FXK OCA].
- 
-
==Reference==
 
-
Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins., Siegert R, Leroux MR, Scheufler C, Hartl FU, Moarefi I, Cell. 2000 Nov 10;103(4):621-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11106732 11106732]
 
[[Category: Chaperones]]
[[Category: Chaperones]]
[[Category: Moarefi, I.]]
[[Category: Moarefi, I.]]
Line 25: Line 21:
[[Category: Siegert, R.]]
[[Category: Siegert, R.]]
[[Category: Archaeal protein]]
[[Category: Archaeal protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:52:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:23:51 2008''

Revision as of 14:23, 26 June 2008

Image:1fxk.png

Template:STRUCTURE 1fxk

CRYSTAL STRUCTURE OF ARCHAEAL PREFOLDIN (GIMC).


Template:ABSTRACT 11106732

About this Structure

The following page contains interesting information on the relation of 1FXK with [Chaperones]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:23:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fxk"
Personal tools