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1gh6

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[[Image:1gh6.gif|left|200px]]
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[[Image:1gh6.png|left|200px]]
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==Overview==
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{{ABSTRACT_11226179}}
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Inactivation of the retinoblastoma (Rb) tumor suppressor by Simian virus 40 (SV40) large T antigen is one of the central features of tumorigenesis induced by SV40. Both the N-terminal J domain and the LxCxE motif of large T antigen are required for inactivation of Rb. The crystal structure of the N-terminal region (residues 7-117) of SV40 large T antigen bound to the pocket domain of Rb reveals that large T antigen contains a four-helix bundle, and residues from helices alpha2 and alpha4 and from a loop containing the LxCxE motif participate in the interactions with Rb. The two central helices and a connecting loop in large T antigen have structural similarities with the J domains of the molecular chaperones DnaJ and HDJ-1, suggesting that large T antigen may use a chaperone mechanism for its biological function. However, there are significant differences between large T antigen and the molecular chaperones in other regions and these differences are likely to provide the specificity needed for large T antigen to inactivate Rb.
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==About this Structure==
==About this Structure==
1GH6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. The following page contains interesting information on the relation of 1GH6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb47_1.html Simian Virus 40]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GH6 OCA].
1GH6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. The following page contains interesting information on the relation of 1GH6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb47_1.html Simian Virus 40]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GH6 OCA].
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==Reference==
 
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Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen., Kim HY, Ahn BY, Cho Y, EMBO J. 2001 Jan 15;20(1-2):295-304. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11226179 11226179]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Oncoprotein]]
[[Category: Oncoprotein]]
[[Category: Tumor suppressor]]
[[Category: Tumor suppressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:33:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:25:28 2008''

Revision as of 14:25, 26 June 2008

Image:1gh6.png

Template:STRUCTURE 1gh6

RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN


Template:ABSTRACT 11226179

About this Structure

1GH6 is a Protein complex structure of sequences from Homo sapiens and Simian virus 40. The following page contains interesting information on the relation of 1GH6 with [Simian Virus 40]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:25:28 2008

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