1pah

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[[Image:1pah.gif|left|200px]]
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==Overview==
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{{ABSTRACT_9406548}}
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The 2.0 A crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals a fold similar to that of tyrosine hydroxylase. It provides the first structural view of where mutations occur and a rationale to explain molecular mechanisms of the enzymatic phenotypes in the autosomal recessive disorder phenylketoneuria.
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==About this Structure==
==About this Structure==
1PAH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1PAH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAH OCA].
1PAH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1PAH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAH OCA].
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==Reference==
 
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Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria., Erlandsen H, Fusetti F, Martinez A, Hough E, Flatmark T, Stevens RC, Nat Struct Biol. 1997 Dec;4(12):995-1000. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9406548 9406548]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylalanine 4-monooxygenase]]
[[Category: Phenylalanine 4-monooxygenase]]
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[[Category: Phenylketonuria]]
[[Category: Phenylketonuria]]
[[Category: Pku]]
[[Category: Pku]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:52:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:48:45 2008''

Revision as of 14:48, 26 June 2008

Template:STRUCTURE 1pah

HUMAN PHENYLALANINE HYDROXYLASE DIMER, RESIDUES 117-424


Template:ABSTRACT 9406548

About this Structure

1PAH is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1PAH with [Phenylalanine Hydroxylase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:48:45 2008

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