1v0d

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[[Image:1v0d.gif|left|200px]]
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[[Image:1v0d.png|left|200px]]
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==Overview==
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{{ABSTRACT_15149602}}
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CAD/DFF40 is responsible for the degradation of chromosomal DNA into nucleosomal fragments and subsequent chromatin condensation during apoptosis. It exists as an inactive complex with its inhibitor ICAD/DFF45 in proliferating cells but becomes activated upon cleavage of ICAD/DFF45 into three domains by caspases in dying cells. The molecular mechanism underlying the control and activation of CAD/DFF40 was unknown. Here, the crystal structure of activated CAD/DFF40 reveals that it is a pair of molecular scissors with a deep active-site crevice that appears ideal for distinguishing internucleosomal DNA from nucleosomal DNA. Ensuing studies show that ICAD/DFF45 sequesters the nonfunctional CAD/DFF40 monomer and is also able to disassemble the functional CAD/DFF40 dimer. This capacity requires the involvement of the middle domain of ICAD/DFF45, which by itself cannot remain bound to CAD/DFF40 due to low binding affinity for the enzyme. Thus, the consequence of the caspase-cleavage of ICAD/DFF45 is a self-assembly of CAD/DFF40 into the active dimer.
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==About this Structure==
==About this Structure==
1V0D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1V0D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb56_1.html Caspases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0D OCA].
1V0D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1V0D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb56_1.html Caspases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V0D OCA].
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==Reference==
 
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Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway., Woo EJ, Kim YG, Kim MS, Han WD, Shin S, Robinson H, Park SY, Oh BH, Mol Cell. 2004 May 21;14(4):531-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15149602 15149602]
 
[[Category: Caspases]]
[[Category: Caspases]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Nuclease]]
[[Category: Nuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:55:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:04:16 2008''

Revision as of 15:04, 26 June 2008

Image:1v0d.png

Template:STRUCTURE 1v0d

CRYSTAL STRUCTURE OF CASPASE-ACTIVATED DNASE (CAD)


Template:ABSTRACT 15149602

About this Structure

1V0D is a Single protein structure of sequence from Mus musculus. The following page contains interesting information on the relation of 1V0D with [Caspases]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:04:16 2008

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