1w0e

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[[Image:1w0e.gif|left|200px]]
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==Overview==
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{{ABSTRACT_15256616}}
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Cytochromes P450 (P450s) metabolize a wide range of endogenous compounds and xenobiotics, such as pollutants, environmental compounds, and drug molecules. The microsomal, membrane-associated, P450 isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP2E1, and CYP1A2 are responsible for the oxidative metabolism of more than 90% of marketed drugs. Cytochrome P450 3A4 (CYP3A4) metabolizes more drug molecules than all other isoforms combined. Here we report three crystal structures of CYP3A4: unliganded, bound to the inhibitor metyrapone, and bound to the substrate progesterone. The structures revealed a surprisingly small active site, with little conformational change associated with the binding of either compound. An unexpected peripheral binding site is identified, located above a phenylalanine cluster, which may be involved in the initial recognition of substrates or allosteric effectors.
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==About this Structure==
==About this Structure==
1W0E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1W0E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb82_1.html Cytochrome p450]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0E OCA].
1W0E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1W0E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb82_1.html Cytochrome p450]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0E OCA].
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==Reference==
 
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Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone., Williams PA, Cosme J, Vinkovic DM, Ward A, Angove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti H, Science. 2004 Jul 30;305(5684):683-6. Epub 2004 Jul 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15256616 15256616]
 
[[Category: Cytochrome p450]]
[[Category: Cytochrome p450]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nifedipine oxidase]]
[[Category: Nifedipine oxidase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:59:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:05:23 2008''

Revision as of 15:05, 26 June 2008

Image:1w0e.png

Template:STRUCTURE 1w0e

CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4


Template:ABSTRACT 15256616

About this Structure

1W0E is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1W0E with [Cytochrome p450]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:05:23 2008

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