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1z1g

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[[Image:1z1g.gif|left|200px]]
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[[Image:1z1g.png|left|200px]]
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==Overview==
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{{ABSTRACT_15973401}}
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Site-specific DNA recombination is important for basic cellular functions including viral integration, control of gene expression, production of genetic diversity and segregation of newly replicated chromosomes, and is used by bacteriophage lambda to integrate or excise its genome into and out of the host chromosome. lambda recombination is carried out by the bacteriophage-encoded integrase protein (lambda-int) together with accessory DNA sites and associated bending proteins that allow regulation in response to cell physiology. Here we report the crystal structures of lambda-int in higher-order complexes with substrates and regulatory DNAs representing different intermediates along the reaction pathway. The structures show how the simultaneous binding of two separate domains of lambda-int to DNA facilitates synapsis and can specify the order of DNA strand cleavage and exchange. An intertwined layer of amino-terminal domains bound to accessory (arm) DNAs shapes the recombination complex in a way that suggests how arm binding shifts the reaction equilibrium in favour of recombinant products.
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==About this Structure==
==About this Structure==
1Z1G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. The following page contains interesting information on the relation of 1Z1G with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb84_1.html Transposase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1G OCA].
1Z1G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. The following page contains interesting information on the relation of 1Z1G with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb84_1.html Transposase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1G OCA].
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==Reference==
 
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A structural basis for allosteric control of DNA recombination by lambda integrase., Biswas T, Aihara H, Radman-Livaja M, Filman D, Landy A, Ellenberger T, Nature. 2005 Jun 23;435(7045):1059-66. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15973401 15973401]
 
[[Category: Enterobacteria phage lambda]]
[[Category: Enterobacteria phage lambda]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Radman-Livaja, M.]]
[[Category: Radman-Livaja, M.]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:04:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:09:52 2008''

Revision as of 15:09, 26 June 2008

Image:1z1g.png

Template:STRUCTURE 1z1g

Crystal structure of a lambda integrase tetramer bound to a Holliday junction


Template:ABSTRACT 15973401

About this Structure

1Z1G is a Single protein structure of sequence from Enterobacteria phage lambda. The following page contains interesting information on the relation of 1Z1G with [Transposase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:09:52 2008

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