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2drd

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[[Image:2drd.gif|left|200px]]
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[[Image:2drd.png|left|200px]]
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==Overview==
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{{ABSTRACT_16915237}}
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AcrB is a principal multidrug efflux transporter in Escherichia coli that cooperates with an outer-membrane channel, TolC, and a membrane-fusion protein, AcrA. Here we describe crystal structures of AcrB with and without substrates. The AcrB-drug complex consists of three protomers, each of which has a different conformation corresponding to one of the three functional states of the transport cycle. Bound substrate was found in the periplasmic domain of one of the three protomers. The voluminous binding pocket is aromatic and allows multi-site binding. The structures indicate that drugs are exported by a three-step functionally rotating mechanism in which substrates undergo ordered binding change.
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==About this Structure==
==About this Structure==
2DRD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DRD OCA].
2DRD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DRD OCA].
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==Reference==
 
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Crystal structures of a multidrug transporter reveal a functionally rotating mechanism., Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A, Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16915237 16915237]
 
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Multidrug efflux]]
[[Category: Multidrug efflux]]
[[Category: Transporter]]
[[Category: Transporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:00:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:15:40 2008''

Revision as of 15:15, 26 June 2008

Image:2drd.png

Template:STRUCTURE 2drd

Crystal structure of a multidrug transporter reveal a functionally rotating mechanism


Template:ABSTRACT 16915237

About this Structure

2DRD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:15:40 2008

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