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2hgh

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[[Image:2hgh.gif|left|200px]]
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[[Image:2hgh.png|left|200px]]
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==Overview==
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{{ABSTRACT_16405997}}
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Transcription factor IIIA (TFIIIA) is a Cys2His2 zinc finger protein that regulates expression of the 5 S ribosomal RNA gene by binding specifically to the internal control element. TFIIIA also functions in transport and storage of 5 S RNA by binding directly to the RNA transcript. To obtain insights into the mechanism by which TFIIIA recognizes 5 S RNA, we determined the solution structure of the middle three zinc fingers bound to the central core of 5 S RNA. Finger 4 utilizes "lock and key" recognition to bind in the widened major groove of the pre-structured RNA loop E motif. This interaction is mediated by direct hydrogen bonding interactions with bases. In contrast, recognition of loop A, a flexible junction of three helices, occurs by an induced fit mechanism that involves reorganization of the conserved CAUA motif and structuring of the finger 5-finger 6 interface to form a complementary RNA binding surface.
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==About this Structure==
==About this Structure==
2HGH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The following page contains interesting information on the relation of 2HGH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGH OCA].
2HGH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The following page contains interesting information on the relation of 2HGH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGH OCA].
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==Reference==
 
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Induced fit and "lock and key" recognition of 5S RNA by zinc fingers of transcription factor IIIA., Lee BM, Xu J, Clarkson BK, Martinez-Yamout MA, Dyson HJ, Case DA, Gottesfeld JM, Wright PE, J Mol Biol. 2006 Mar 17;357(1):275-91. Epub 2005 Dec 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16405997 16405997]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Lee, B M.]]
[[Category: Lee, B M.]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:15:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:18:18 2008''

Revision as of 15:18, 26 June 2008

Image:2hgh.png

Template:STRUCTURE 2hgh

Transcription Factor IIIA zinc fingers 4-6 bound to 5S rRNA 55mer (NMR structure)


Template:ABSTRACT 16405997

About this Structure

2HGH is a Single protein structure of sequence from Xenopus laevis. The following page contains interesting information on the relation of 2HGH with [Zinc Fingers]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:18:18 2008

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