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2onj

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[[Image:2onj.gif|left|200px]]
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[[Image:2onj.png|left|200px]]
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==Overview==
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{{ABSTRACT_17303126}}
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Staphylococcus aureus Sav1866 is a bacterial homolog of the human ABC transporter Mdr1 that causes multidrug resistance in cancer cells. We report the crystal structure of Sav1866 in complex with adenosine-5'-(beta,gamma-imido)triphosphate (AMP-PNP) at 3.4A resolution and compare it with the previously determined structure of Sav1866 with bound ADP. Besides differences in the ATP-binding sites, no significant conformational changes were observed. The results confirm that the ATP-bound state of multidrug ABC transporters is coupled to an outward-facing conformation of the transmembrane domains.
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==About this Structure==
==About this Structure==
2ONJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONJ OCA].
2ONJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONJ OCA].
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==Reference==
 
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Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP., Dawson RJ, Locher KP, FEBS Lett. 2007 Mar 6;581(5):935-8. Epub 2007 Feb 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17303126 17303126]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Integral membrane protein]]
[[Category: Integral membrane protein]]
[[Category: Transport protein]]
[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:16:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:21:01 2008''

Revision as of 15:21, 26 June 2008

Image:2onj.png

Template:STRUCTURE 2onj

Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP


Template:ABSTRACT 17303126

About this Structure

2ONJ is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:21:01 2008

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