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3cyt

From Proteopedia

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[[Image:3cyt.gif|left|200px]]
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[[Image:3cyt.png|left|200px]]
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==Overview==
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{{ABSTRACT_6256733}}
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Tuna ferrocytochrome c and ferricytochrome c have been refined independently at high resolution (1.5 A and 1.8 A) to crystallographic residual errors of 17.3% and 20.8%, respectively. Small but significant conformational differences are seen surrounding a buried water molecule that is hydrogen bonded to Asn-52, Tyr-67, and Thr-78. In the oxidized state, this water molecule is 1.0 A closer to the heme and the heme has moved 0.15 A out of its heme crevice; both changes lead to a more polar microenvironment for the heme. Chemical modification studies, patterns of evolutionary conservatism, structural differences in bacterial cytochromes, and x-ray studies all agree that the "active site" for cytochrome c is bounded by lysines 8, 13,27, 72, 79, 86, and 87 (thus containing the evolutionary conservative 72-87 loop) and has the buried water molecule just below its surface and the opening of the heme crevice slightly to one side.
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==About this Structure==
==About this Structure==
3CYT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thunnus_alalunga Thunnus alalunga]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cyt 1cyt]. The following pages contain interesting information on the relation of 3CYT with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb89_1.html Aconitase and Iron Regulatory Protein 1]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYT OCA].
3CYT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thunnus_alalunga Thunnus alalunga]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cyt 1cyt]. The following pages contain interesting information on the relation of 3CYT with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb89_1.html Aconitase and Iron Regulatory Protein 1]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYT OCA].
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==Reference==
 
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Redox conformation changes in refined tuna cytochrome c., Takano T, Dickerson RE, Proc Natl Acad Sci U S A. 1980 Nov;77(11):6371-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/6256733 6256733]
 
[[Category: Aconitase and Iron Regulatory Protein 1]]
[[Category: Aconitase and Iron Regulatory Protein 1]]
[[Category: Cytochrome c]]
[[Category: Cytochrome c]]
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[[Category: Thunnus alalunga]]
[[Category: Thunnus alalunga]]
[[Category: Takano, T.]]
[[Category: Takano, T.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:59:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:25:49 2008''

Revision as of 15:25, 26 June 2008

Image:3cyt.png

Template:STRUCTURE 3cyt

REDOX CONFORMATION CHANGES IN REFINED TUNA CYTOCHROME C


Template:ABSTRACT 6256733

About this Structure

3CYT is a Single protein structure of sequence from Thunnus alalunga. This structure supersedes the now removed PDB entry 1cyt. The following pages contain interesting information on the relation of 3CYT with [Aconitase and Iron Regulatory Protein 1]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:25:49 2008

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