3kin

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[[Image:3kin.gif|left|200px]]
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==Overview==
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{{ABSTRACT_9428521}}
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The dimeric form of the kinesin motor and neck domain from rat brain with bound ADP has been solved by X-ray crystallography. The two heads of the dimer are connected via a coiled-coil alpha-helical interaction of their necks. They are broadly similar to one another; differences are most apparent in the head-neck junction and in a moderate reorientation of the neck helices in order to adopt to the coiled-coil conformation. The heads show a rotational symmetry (approximately 120 degrees) about an axis close to that of the coiled-coil. This arrangement is unexpected since it is not compatible with the microtubule lattice. In this arrangement, the two heads of a kinesin dimer could not have equivalent interactions with microtubules.
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==About this Structure==
==About this Structure==
3KIN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The following page contains interesting information on the relation of 3KIN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb64_1.html Kinesin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIN OCA].
3KIN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The following page contains interesting information on the relation of 3KIN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb64_1.html Kinesin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIN OCA].
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==Reference==
 
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The crystal structure of dimeric kinesin and implications for microtubule-dependent motility., Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E, Cell. 1997 Dec 26;91(7):985-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9428521 9428521]
 
[[Category: Kinesin]]
[[Category: Kinesin]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Cytoskeleton]]
[[Category: Cytoskeleton]]
[[Category: Motor protein]]
[[Category: Motor protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:05:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:27:13 2008''

Revision as of 15:27, 26 June 2008

Template:STRUCTURE 3kin

KINESIN (DIMERIC) FROM RATTUS NORVEGICUS


Template:ABSTRACT 9428521

About this Structure

3KIN is a Protein complex structure of sequences from Rattus norvegicus. The following page contains interesting information on the relation of 3KIN with [Kinesin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:27:13 2008

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