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1a17

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{{STRUCTURE_1a17| PDB=1a17 | SCENE= }}
{{STRUCTURE_1a17| PDB=1a17 | SCENE= }}
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'''TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5'''
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===TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5===
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==Overview==
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The tetratricopeptide repeat (TPR) is a degenerate 34 amino acid sequence identified in a wide variety of proteins, present in tandem arrays of 3-16 motifs, which form scaffolds to mediate protein-protein interactions and often the assembly of multiprotein complexes. TPR-containing proteins include the anaphase promoting complex (APC) subunits cdc16, cdc23 and cdc27, the NADPH oxidase subunit p67 phox, hsp90-binding immunophilins, transcription factors, the PKR protein kinase inhibitor, and peroxisomal and mitochondrial import proteins. Here, we report the crystal structure of the TPR domain of a protein phosphatase, PP5. Each of the three TPR motifs of this domain consist of a pair of antiparallel alpha-helices of equivalent length. Adjacent TPR motifs are packed together in a parallel arrangement such that a tandem TPR motif structure is composed of a regular series of antiparallel alpha-helices. The uniform angular and spatial arrangement of neighbouring alpha-helices defines a helical structure and creates an amphipathic groove. Multiple-TPR motif proteins would fold into a right-handed super-helical structure with a continuous helical groove suitable for the recognition of target proteins, hence defining a novel mechanism for protein recognition. The spatial arrangement of alpha-helices in the PP5-TPR domain is similar to those within 14-3-3 proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 9482716 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9482716}}
==About this Structure==
==About this Structure==
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[[Category: Tpr]]
[[Category: Tpr]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:39:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:46:16 2008''

Revision as of 12:46, 30 June 2008

Image:1a17.png

Template:STRUCTURE 1a17

TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5

Template:ABSTRACT PUBMED 9482716

About this Structure

1A17 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions., Das AK, Cohen PW, Barford D, EMBO J. 1998 Mar 2;17(5):1192-9. PMID:9482716

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