1a8o

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[[Image:1a8o.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1a8o| PDB=1a8o | SCENE= }}
{{STRUCTURE_1a8o| PDB=1a8o | SCENE= }}
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'''HIV CAPSID C-TERMINAL DOMAIN'''
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===HIV CAPSID C-TERMINAL DOMAIN===
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==Overview==
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The carboxyl-terminal domain, residues 146 to 231, of the human immunodeficiency virus-1 (HIV-1) capsid protein [CA(146-231)] is required for capsid dimerization and viral assembly. This domain contains a stretch of 20 residues, called the major homology region (MHR), which is conserved across retroviruses and is essential for viral assembly, maturation, and infectivity. The crystal structures of CA(146-231) and CA(151-231) reveal that the globular domain is composed of four helices and an extended amino-terminal strand. CA(146-231) dimerizes through parallel packing of helix 2 across a dyad. The MHR is distinct from the dimer interface and instead forms an intricate hydrogen-bonding network that interconnects strand 1 and helices 1 and 2. Alignment of the CA(146-231) dimer with the crystal structure of the capsid amino-terminal domain provides a model for the intact protein and extends models for assembly of the central conical core of HIV-1.
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The line below this paragraph, {{ABSTRACT_PUBMED_9346481}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9346481 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9346481}}
==About this Structure==
==About this Structure==
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[[Category: Core protein]]
[[Category: Core protein]]
[[Category: Hiv]]
[[Category: Hiv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:58:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:23:12 2008''

Revision as of 13:23, 30 June 2008

Image:1a8o.png

Template:STRUCTURE 1a8o

HIV CAPSID C-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 9346481

About this Structure

1A8O is a Single protein structure of sequence from Human immunodeficiency virus 1. This structure supersedes the now removed PDB entry 1am3. Full crystallographic information is available from OCA.

Reference

Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein., Gamble TR, Yoo S, Vajdos FF, von Schwedler UK, Worthylake DK, Wang H, McCutcheon JP, Sundquist WI, Hill CP, Science. 1997 Oct 31;278(5339):849-53. PMID:9346481

Page seeded by OCA on Mon Jun 30 16:23:12 2008

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