1ac8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ac8.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ac8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ac8| PDB=1ac8 | SCENE= }}
{{STRUCTURE_1ac8| PDB=1ac8 | SCENE= }}
-
'''VARIATION IN THE STRENGTH OF A CH TO O HYDROGEN BOND IN AN ARTIFICIAL PROTEIN CAVITY (3,4,5-TRIMETHYLTHIAZOLE)'''
+
===VARIATION IN THE STRENGTH OF A CH TO O HYDROGEN BOND IN AN ARTIFICIAL PROTEIN CAVITY (3,4,5-TRIMETHYLTHIAZOLE)===
-
==Overview==
+
<!--
-
Conformational changes that gate the access of substrates or ligands to an active site are important features of enzyme function. In this report, we describe an unusual example of a structural rearrangement near a buried artificial cavity in cytochrome c peroxidase that occurs on binding protonated benzimidazole. A hinged main-chain rotation at two residues (Pro 190 and Asn 195) results in a surface loop rearrangement that opens a large solvent-accessible channel for the entry of ligands to an otherwise inaccessible binding site. The trapping of this alternate conformational state provides a unique view of the extent to which protein dynamics can allow small molecule penetration into buried protein cavities.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8673607}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8673607 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8673607}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Peroxidase]]
[[Category: Peroxidase]]
[[Category: Transit peptide]]
[[Category: Transit peptide]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:05:35 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:34:05 2008''

Revision as of 13:34, 30 June 2008

Image:1ac8.png

Template:STRUCTURE 1ac8

VARIATION IN THE STRENGTH OF A CH TO O HYDROGEN BOND IN AN ARTIFICIAL PROTEIN CAVITY (3,4,5-TRIMETHYLTHIAZOLE)

Template:ABSTRACT PUBMED 8673607

About this Structure

1AC8 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

A ligand-gated, hinged loop rearrangement opens a channel to a buried artificial protein cavity., Fitzgerald MM, Musah RA, McRee DE, Goodin DB, Nat Struct Biol. 1996 Jul;3(7):626-31. PMID:8673607

Page seeded by OCA on Mon Jun 30 16:34:05 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ac8"
Personal tools