1ad6

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[[Image:1ad6.gif|left|200px]]
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{{STRUCTURE_1ad6| PDB=1ad6 | SCENE= }}
{{STRUCTURE_1ad6| PDB=1ad6 | SCENE= }}
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'''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR'''
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===DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR===
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==Overview==
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The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.
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(as it appears on PubMed at http://www.pubmed.gov), where 9145110 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9145110}}
==About this Structure==
==About this Structure==
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[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Tumor suppressor]]
[[Category: Tumor suppressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:07:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:36:39 2008''

Revision as of 13:36, 30 June 2008

Image:1ad6.png

Template:STRUCTURE 1ad6

DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR

Template:ABSTRACT PUBMED 9145110

About this Structure

1AD6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box., Kim HY, Cho Y, Nat Struct Biol. 1997 May;4(5):390-5. PMID:9145110

Page seeded by OCA on Mon Jun 30 16:36:39 2008

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