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1adq

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[[Image:1adq.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1adq| PDB=1adq | SCENE= }}
{{STRUCTURE_1adq| PDB=1adq | SCENE= }}
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'''CRYSTAL STRUCTURE OF A HUMAN IGM RHEUMATOID FACTOR FAB IN COMPLEX WITH ITS AUTOANTIGEN IGG FC'''
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===CRYSTAL STRUCTURE OF A HUMAN IGM RHEUMATOID FACTOR FAB IN COMPLEX WITH ITS AUTOANTIGEN IGG FC===
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==Overview==
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Rheumatoid factors are the characteristic autoantibodies of rheumatoid arthritis, which bind to the Fc regions of IgG molecules. Here we report the crystal structure of the Fab fragment of a patient-derived IgM rheumatoid factor (RF-AN) complexed with human IgG4 Fc, at 3.2 A resolution. This is the first structure of an autoantibody-autoantigen complex. The epitope recognised in IgG Fc includes the C gamma 2/C gamma 3 cleft region, and overlaps the binding sites of bacterial Fc-binding proteins. The antibody residues involved in autorecognition are all located at the edge of the conventional combining site surface, leaving much of the latter available, potentially, for recognition of a different antigen. Since an important contact residue is somatic mutation, the structure implicates antigen-driven selection, following somatic mutation of germline genes, in the production of pathogenic rheumatoid factors.
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The line below this paragraph, {{ABSTRACT_PUBMED_9145108}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9145108 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9145108}}
==About this Structure==
==About this Structure==
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[[Category: Taussig, M J.]]
[[Category: Taussig, M J.]]
[[Category: Rheumatoid factor auto-antibody complex]]
[[Category: Rheumatoid factor auto-antibody complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:08:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:38:07 2008''

Revision as of 13:38, 30 June 2008

Image:1adq.png

Template:STRUCTURE 1adq

CRYSTAL STRUCTURE OF A HUMAN IGM RHEUMATOID FACTOR FAB IN COMPLEX WITH ITS AUTOANTIGEN IGG FC

Template:ABSTRACT PUBMED 9145108

About this Structure

1ADQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction., Corper AL, Sohi MK, Bonagura VR, Steinitz M, Jefferis R, Feinstein A, Beale D, Taussig MJ, Sutton BJ, Nat Struct Biol. 1997 May;4(5):374-81. PMID:9145108

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