1alu

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{{Seed}}
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{{STRUCTURE_1alu| PDB=1alu | SCENE= }}
{{STRUCTURE_1alu| PDB=1alu | SCENE= }}
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'''HUMAN INTERLEUKIN-6'''
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===HUMAN INTERLEUKIN-6===
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==Overview==
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Interleukin 6 (IL-6) has many biological activities in vivo, and deregulation has been implicated in many disease processes. IL-6, a 185 amino acid polypeptide was refolded, purified and crystallized. The crystals diffracted to beyond 1.9 A and the structure was solved using single isomorphous replacement. The X-ray structure of IL-6 is composed of a four helix bundle linked by loops and an additional mini-helix. 157 out of 185 residues are well defined in the final structure, with 18 N-terminal and 8 A-B loop amino acids displaying no interpretable electron density. The three-dimensional structure has been used to construct a model of IL-6 interacting with the IL-6 receptor (alpha-chain) and gp130 (beta-chain) that gives new insight into the process of molecular recognition and signaling. Based on this model, we predict a fourth binding site on IL-6, a low affinity IL-6-IL-6 interaction, which may be necessary for the sequential assembly of a functional hexameric IL-6 receptor complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 9118960 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9118960}}
==About this Structure==
==About this Structure==
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[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Signaling]]
[[Category: Signaling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:25:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:07:02 2008''

Revision as of 14:07, 30 June 2008

Image:1alu.png

Template:STRUCTURE 1alu

HUMAN INTERLEUKIN-6

Template:ABSTRACT PUBMED 9118960

About this Structure

1ALU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling., Somers W, Stahl M, Seehra JS, EMBO J. 1997 Mar 3;16(5):989-97. PMID:9118960

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