This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1aly

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1aly.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1aly.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1aly| PDB=1aly | SCENE= }}
{{STRUCTURE_1aly| PDB=1aly | SCENE= }}
-
'''CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND'''
+
===CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND===
-
==Overview==
+
<!--
-
BACKGROUND: The CD40 ligand (CD40L) is a member of the tumor necrosis factor (TNF) family of proteins and is transiently expressed on the surface of activated T cells. The binding of CD40L to CD40, which is expressed on the surface of B cells, provides a critical and unique pathway of cellular activation resulting in antibody isotype switching, regulation of apoptosis, and B cell proliferation and differentiation. Naturally occurring mutations of CD40L result in the clinical hyper-IgM syndrome, characterized by an inability to produce immunoglobulins of the IgG, IgA and IgE isotypes. RESULTS: We have determined the crystal structure of a soluble extracellular fragment of human CD40L to 2 A resolution and with an R factor of 21.8%. Although the molecule forms a trimer similar to that found for other members of the TNF family, such as TNF alpha and lymphotoxin-alpha, and exhibits a similar overall fold, there are considerable differences in several loops including those predicted to be involved in CD40 binding. CONCLUSIONS: The structure suggests that most of the hyper-IgM syndrome mutations affect the folding and stability of the molecule rather than the CD40-binding site directly. Despite the fact that the hyper-IgM syndrome mutations are dispersed in the primary sequence, a large fraction of them are clustered in space in the vicinity of a surface loop, close to the predicted CD40-binding site.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8589998}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8589998 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8589998}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Hyper-igm syndrome]]
[[Category: Hyper-igm syndrome]]
[[Category: Tnf]]
[[Category: Tnf]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:26:03 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:07:29 2008''

Revision as of 14:07, 30 June 2008

Image:1aly.png

Template:STRUCTURE 1aly

CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND

Template:ABSTRACT PUBMED 8589998

About this Structure

1ALY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

2 A crystal structure of an extracellular fragment of human CD40 ligand., Karpusas M, Hsu YM, Wang JH, Thompson J, Lederman S, Chess L, Thomas D, Structure. 1995 Oct 15;3(10):1031-9. PMID:8589998

Page seeded by OCA on Mon Jun 30 17:07:29 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aly"
Personal tools