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1amm

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{{STRUCTURE_1amm| PDB=1amm | SCENE= }}
{{STRUCTURE_1amm| PDB=1amm | SCENE= }}
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'''1.2 ANGSTROM STRUCTURE OF GAMMA-B CRYSTALLIN AT 150K'''
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===1.2 ANGSTROM STRUCTURE OF GAMMA-B CRYSTALLIN AT 150K===
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==Overview==
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gammabeta-crystallin is a structural protein of the eye lens with a role in the maintenance of an even distribution of protein and water over distances around the wavelength of light, preserving lens transparency. The structure of the 174-residue bovine protein has already been determined at room temperature to 1.47 A resolution. By flash freezing the protein crystals, data have now been collected to a nominal resolution limit of 1.2 A as radiation damage was essentially eliminated. The protein-water model has been refined against this data using the program RESTRAIN converging to an R factor of 18.5% with all data. Atomic positions are clearly indicated in the electron-density maps. Discrete bimodal disorder has been visualized for a few side chains. Out of a total of 498 water molecules present in the crystal asymmetric unit, 394 have been modelled and refined at unit occupancy. The solvent structure is extremely well ordered with an average B value of 23.4 A(2). Partially occupied sites have been identified where disorder in the protein induces concomitant disorder in the local solvent structure. The solvent structure covers 97% of the solvent-exposed surface of the protein in the crystal. 126 water molecules are distributed in second and higher hydration shells. There are networks of hydrogen-bonded solvent extending up to 64 molecules in a network, comprising trimers and tetramers as well as five- and six-membered water-ring structures. The hydration of the protein surface is dominated by arginine and aspartate side chains. Extensive cages of highly ordered solvent molecules are also observed around exposed non-polar groups.
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(as it appears on PubMed at http://www.pubmed.gov), where 15299624 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15299624}}
==About this Structure==
==About this Structure==
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[[Category: Crystallin]]
[[Category: Crystallin]]
[[Category: Eye lens protein]]
[[Category: Eye lens protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:27:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:10:07 2008''

Revision as of 14:10, 30 June 2008

Image:1amm.png

Template:STRUCTURE 1amm

1.2 ANGSTROM STRUCTURE OF GAMMA-B CRYSTALLIN AT 150K

Template:ABSTRACT PUBMED 15299624

About this Structure

1AMM is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

An eye lens protein-water structure: 1.2 A resolution structure of gammaB-crystallin at 150 K., Kumaraswamy VS, Lindley PF, Slingsby C, Glover ID, Acta Crystallogr D Biol Crystallogr. 1996 Jul 1;52(Pt 4):611-22. PMID:15299624

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