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1amx

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{{STRUCTURE_1amx| PDB=1amx | SCENE= }}
{{STRUCTURE_1amx| PDB=1amx | SCENE= }}
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'''COLLAGEN-BINDING DOMAIN FROM A STAPHYLOCOCCUS AUREUS ADHESIN'''
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===COLLAGEN-BINDING DOMAIN FROM A STAPHYLOCOCCUS AUREUS ADHESIN===
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==Overview==
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The crystal structure of the recombinant 19,000 M(r) binding domain from the Staphylococcus aureus collagen adhesin has been determined at 2 A resolution. The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices. Triple-helical collagen model probes were used in a systematic docking search to identify the collagen-binding site. A groove on beta-sheet I exhibited the best surface complementarity to the collagen probes. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen. Here we present a structural perspective for the mode of collagen binding by a bacterial surface protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 9334749 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9334749}}
==About this Structure==
==About this Structure==
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[[Category: Bacterial adhesin]]
[[Category: Bacterial adhesin]]
[[Category: Mscramm]]
[[Category: Mscramm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:27:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:11:25 2008''

Revision as of 14:11, 30 June 2008

Image:1amx.png

Template:STRUCTURE 1amx

COLLAGEN-BINDING DOMAIN FROM A STAPHYLOCOCCUS AUREUS ADHESIN

Template:ABSTRACT PUBMED 9334749

About this Structure

1AMX is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structure of the collagen-binding domain from a Staphylococcus aureus adhesin., Symersky J, Patti JM, Carson M, House-Pompeo K, Teale M, Moore D, Jin L, Schneider A, DeLucas LJ, Hook M, Narayana SV, Nat Struct Biol. 1997 Oct;4(10):833-8. PMID:9334749

Page seeded by OCA on Mon Jun 30 17:11:25 2008

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