1ank

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{{STRUCTURE_1ank| PDB=1ank | SCENE= }}
{{STRUCTURE_1ank| PDB=1ank | SCENE= }}
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'''THE CLOSED CONFORMATION OF A HIGHLY FLEXIBLE PROTEIN: THE STRUCTURE OF E. CLOI ADENYLATE KINASE WITH BOUND AMP AND AMPPNP'''
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===THE CLOSED CONFORMATION OF A HIGHLY FLEXIBLE PROTEIN: THE STRUCTURE OF E. CLOI ADENYLATE KINASE WITH BOUND AMP AND AMPPNP===
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==Overview==
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The structure of E. coli adenylate kinase with bound AMP and AMPPNP at 2.0 A resolution is presented. The protein crystallizes in space group C2 with two molecules in the asymmetric unit, and has been refined to an R factor of 20.1% and an Rfree of 31.6%. In the present structure, the protein is in the closed (globular) form with the large flexible lid domain covering the AMPPNP molecule. Within the protein, AMP and AMPPNP, and ATP analog, occupy the AMP and ATP sites respectively, which had been suggested by the most recent crystal structure of E. coli adenylate kinase with Ap5A bound (Muller and Schulz, 1992, ref. 1) and prior fluorescence studies (Liang et al., 1991, ref. 2). The binding of substrates and the positions of the active site residues are compared between the present structure and the E. coli adenylate kinase/Ap5A structure. We failed to detect a peak in the density map corresponding to the Mg2+ ion which is required for catalysis, and its absence has been attributed to the use of ammonium sulfate in the crystallization solution. Finally, a comparison is made between the present structure and the structure of the heavy chain of muscle myosin.
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(as it appears on PubMed at http://www.pubmed.gov), where 7937733 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7937733}}
==About this Structure==
==About this Structure==
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[[Category: Liang, P.]]
[[Category: Liang, P.]]
[[Category: Meador, B.]]
[[Category: Meador, B.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:13:22 2008''

Revision as of 14:13, 30 June 2008

Image:1ank.png

Template:STRUCTURE 1ank

THE CLOSED CONFORMATION OF A HIGHLY FLEXIBLE PROTEIN: THE STRUCTURE OF E. CLOI ADENYLATE KINASE WITH BOUND AMP AND AMPPNP

Template:ABSTRACT PUBMED 7937733

About this Structure

1ANK is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The closed conformation of a highly flexible protein: the structure of E. coli adenylate kinase with bound AMP and AMPPNP., Berry MB, Meador B, Bilderback T, Liang P, Glaser M, Phillips GN Jr, Proteins. 1994 Jul;19(3):183-98. PMID:7937733

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