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1aoy

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[[Image:1aoy.jpg|left|200px]]
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{{STRUCTURE_1aoy| PDB=1aoy | SCENE= }}
{{STRUCTURE_1aoy| PDB=1aoy | SCENE= }}
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'''N-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR NMR, 23 STRUCTURES'''
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===N-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR NMR, 23 STRUCTURES===
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==Overview==
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The structure of the monomeric DNA-binding domain of the Escherichia coli arginine repressor, ArgR, determined by NMR spectroscopy, shows structural homology to the winged helix-turn-helix (wHTH) family, a motif found in a diverse class of proteins including both gene regulators and gene organizers from prokaryotes and eukaryotes. Biochemical data on DNA binding by intact ArgR are used as constraints to position the domain on its DNA target and to derive a model for the hexamer-DNA complex using the known structure of the L-arginine-binding domain. The structural independence of the wHTH fold may be important for multimeric DNA-binding proteins that contact extended DNA regions with imperfect match to consensus sequences, a feature of many wHTH-domain proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 9334747 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9334747}}
==About this Structure==
==About this Structure==
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1AOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOY OCA].
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1AOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOY OCA].
==Reference==
==Reference==
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[[Category: Expression regulation]]
[[Category: Expression regulation]]
[[Category: Winged helix]]
[[Category: Winged helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:32:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:19:33 2008''

Revision as of 14:19, 30 June 2008

Image:1aoy.png

Template:STRUCTURE 1aoy

N-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR NMR, 23 STRUCTURES

Template:ABSTRACT PUBMED 9334747

About this Structure

1AOY is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Solution structure of the DNA-binding domain and model for the complex of multifunctional hexameric arginine repressor with DNA., Sunnerhagen M, Nilges M, Otting G, Carey J, Nat Struct Biol. 1997 Oct;4(10):819-26. PMID:9334747

Page seeded by OCA on Mon Jun 30 17:19:33 2008

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