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1axc

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[[Image:1axc.gif|left|200px]]
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{{STRUCTURE_1axc| PDB=1axc | SCENE= }}
{{STRUCTURE_1axc| PDB=1axc | SCENE= }}
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'''HUMAN PCNA'''
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===HUMAN PCNA===
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==Overview==
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The crystal structure of the human DNA polymerase delta processivity factor PCNA (proliferating cell nuclear antigen) complexed with a 22 residue peptide derived from the C-terminus of the cell-cycle checkpoint protein p21(WAF1/CIP1) has been determined at 2.6 angstrom resolution. p21 binds to PCNA in a 1:1 stoichiometry with an extensive array of interactions that include the formation of a beta sheet with the interdomain connector loop of PCNA. An intact trimeric ring is maintained in the structure of the p21-PCNA complex, with a central hole available for DNA interaction. The ability of p21 to inhibit the action of PCNA is therefore likely to be due to its masking of elements on PCNA that are required for the binding of other components of the polymerase assembly.
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(as it appears on PubMed at http://www.pubmed.gov), where 8861913 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8861913}}
==About this Structure==
==About this Structure==
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[[Category: Replication]]
[[Category: Replication]]
[[Category: Waf1]]
[[Category: Waf1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:48:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:47:33 2008''

Revision as of 14:47, 30 June 2008

Image:1axc.png

Template:STRUCTURE 1axc

HUMAN PCNA

Template:ABSTRACT PUBMED 8861913

About this Structure

1AXC is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA., Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J, Cell. 1996 Oct 18;87(2):297-306. PMID:8861913

Page seeded by OCA on Mon Jun 30 17:47:33 2008

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