1axh

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[[Image:1axh.gif|left|200px]]
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{{Seed}}
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[[Image:1axh.png|left|200px]]
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{{STRUCTURE_1axh| PDB=1axh | SCENE= }}
{{STRUCTURE_1axh| PDB=1axh | SCENE= }}
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'''ATRACOTOXIN-HVI FROM HADRONYCHE VERSUTA (AUSTRALIAN FUNNEL-WEB SPIDER, NMR, 20 STRUCTURES'''
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===ATRACOTOXIN-HVI FROM HADRONYCHE VERSUTA (AUSTRALIAN FUNNEL-WEB SPIDER, NMR, 20 STRUCTURES===
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==Overview==
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A family of potent insecticidal toxins has recently been isolated from the venom of Australian funnel web spiders. Among these is the 37-residue peptide omega-atracotoxin-HV1 (omega-ACTX-HV1) from Hadronyche versuta. We have chemically synthesized and folded omega-ACTX-HV1, shown that it is neurotoxic, ascertained its disulphide bonding pattern, and determined its three-dimensional solution structure using NMR spectroscopy. The structure consists of a solvent-accessible beta-hairpin protruding from a disulphide-bonded globular core comprising four beta-turns. The three intramolecular disulphide bonds from a cystine knot motif similar to that seen in several other neurotoxic peptides. Despite limited sequence identity, omega-ACTX-HV1 displays significant structural homology with the omega-agatoxins and omega-conotoxins, both of which are vertebrate calcium channel antagonists; however, in contrast with these toxins, we show that omega-ACTX-HV1 inhibits insect, but not mammalian, voltage-gated calcium channel currents.
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(as it appears on PubMed at http://www.pubmed.gov), where 9228949 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9228949}}
==About this Structure==
==About this Structure==
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1AXH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hadronyche_versuta Hadronyche versuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AXH OCA].
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1AXH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hadronyche_versuta Hadronyche versuta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AXH OCA].
==Reference==
==Reference==
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[[Category: Insecticidal toxin]]
[[Category: Insecticidal toxin]]
[[Category: Neurotoxin]]
[[Category: Neurotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:48:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:48:17 2008''

Revision as of 14:48, 30 June 2008

Image:1axh.png

Template:STRUCTURE 1axh

ATRACOTOXIN-HVI FROM HADRONYCHE VERSUTA (AUSTRALIAN FUNNEL-WEB SPIDER, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 9228949

About this Structure

1AXH is a Single protein structure of sequence from Hadronyche versuta. Full experimental information is available from OCA.

Reference

The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider., Fletcher JI, Smith R, O'Donoghue SI, Nilges M, Connor M, Howden ME, Christie MJ, King GF, Nat Struct Biol. 1997 Jul;4(7):559-66. PMID:9228949

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