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1axn

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[[Image:1axn.gif|left|200px]]
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{{STRUCTURE_1axn| PDB=1axn | SCENE= }}
{{STRUCTURE_1axn| PDB=1axn | SCENE= }}
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'''THE HIGH RESOLUTION STRUCTURE OF ANNEXIN III SHOWS DIFFERENCES WITH ANNEXIN V'''
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===THE HIGH RESOLUTION STRUCTURE OF ANNEXIN III SHOWS DIFFERENCES WITH ANNEXIN V===
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==Overview==
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The structure of recombinant human annexin III was solved to 1.8 A resolution. Though homologous to annexin I and V, the annexin III structure shows significant differences. The tryptophan in the calcium loop of the third domain is exposed to the solvent, as in the structure of annexin V crystallized in high calcium concentrations, although the annexin III crystals were prepared at low calcium concentrations. The position of domain III relative to the other domains is different from both annexin V and I, suggesting further flexibility of the molecule. The entire N-terminus of the protein is well-defined in the present structure. The side chain of tryptophan 5 interacts with the hinge region of the hydrophillic channel, which could have an effect on the potential mobility of this region, as well as on its possible calcium channel behavior.
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The line below this paragraph, {{ABSTRACT_PUBMED_8639653}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8639653 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8639653}}
==About this Structure==
==About this Structure==
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[[Category: Russo-Marie, F.]]
[[Category: Russo-Marie, F.]]
[[Category: Annexin family]]
[[Category: Annexin family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:49:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:48:48 2008''

Revision as of 14:48, 30 June 2008

Image:1axn.png

Template:STRUCTURE 1axn

THE HIGH RESOLUTION STRUCTURE OF ANNEXIN III SHOWS DIFFERENCES WITH ANNEXIN V

Template:ABSTRACT PUBMED 8639653

About this Structure

1AXN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The high-resolution crystal structure of human annexin III shows subtle differences with annexin V., Favier-Perron B, Lewit-Bentley A, Russo-Marie F, Biochemistry. 1996 Feb 13;35(6):1740-4. PMID:8639653

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