This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1azv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1azv.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1azv.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1azv| PDB=1azv | SCENE= }}
{{STRUCTURE_1azv| PDB=1azv | SCENE= }}
-
'''FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN)'''
+
===FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN)===
-
==Overview==
+
<!--
-
The X-ray crystal structure of a human copper/zinc superoxide dismutase mutant (G37R CuZnSOD) found in some patients with the inherited form of Lou Gehrig's disease (FALS) has been determined to 1.9 angstroms resolution. The two SOD subunits have distinct environments in the crystal and are different in structure at their copper binding sites. One subunit (subunit[intact]) shows a four-coordinate ligand geometry of the copper ion, whereas the other subunit (subunit[broken]) shows a three-coordinate geometry of the copper ion. Also, subunit(intact) displays higher atomic displacement parameters for backbone atoms ((B) = 30 +/- 10 angstroms2) than subunit(broken) ((B) = 24 +/- 11 angstroms2). This structure is the first CuZnSOD to show large differences between the two subunits. Factors that may contribute to these differences are discussed and a possible link of a looser structure to FALS is suggested.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9541385}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9541385 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9541385}}
==Disease==
==Disease==
Line 36: Line 40:
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Superoxide acceptor]]
[[Category: Superoxide acceptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:53:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:56:24 2008''

Revision as of 14:56, 30 June 2008

Image:1azv.png

Template:STRUCTURE 1azv

Contents

FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN)

Template:ABSTRACT PUBMED 9541385

Disease

Known disease associated with this structure: Amyotrophic lateral sclerosis, due to SOD1 deficiency OMIM:[147450]

About this Structure

1AZV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis., Hart PJ, Liu H, Pellegrini M, Nersissian AM, Gralla EB, Valentine JS, Eisenberg D, Protein Sci. 1998 Mar;7(3):545-55. PMID:9541385

Page seeded by OCA on Mon Jun 30 17:56:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1azv"
Personal tools