1b3n

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{{Seed}}
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{{STRUCTURE_1b3n| PDB=1b3n | SCENE= }}
{{STRUCTURE_1b3n| PDB=1b3n | SCENE= }}
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'''BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN.'''
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===BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN.===
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==Overview==
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In the biosynthesis of fatty acids, the beta-ketoacyl-acyl carrier protein (ACP) synthases catalyze chain elongation by the addition of two-carbon units derived from malonyl-ACP to an acyl group bound to either ACP or CoA. The enzyme is a possible drug target for treatment of certain cancers and for tuberculosis. The crystal structure of the complex of the enzyme from Escherichia coli, and the fungal mycotoxin cerulenin reveals that the inhibitor is bound in a hydrophobic pocket formed at the dimer interface. Cerulenin is covalently attached to the active site cysteine through its C2 carbon atom. The fit of the inhibitor to the active site is not optimal, and there is thus room for improvement through structure based design.
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(as it appears on PubMed at http://www.pubmed.gov), where 10037680 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10037680}}
==About this Structure==
==About this Structure==
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[[Category: Fatty acid elongation]]
[[Category: Fatty acid elongation]]
[[Category: Lipid metabolism]]
[[Category: Lipid metabolism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:01:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:10:12 2008''

Revision as of 15:10, 30 June 2008

Image:1b3n.png

Template:STRUCTURE 1b3n

BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN.

Template:ABSTRACT PUBMED 10037680

About this Structure

1B3N is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase., Moche M, Schneider G, Edwards P, Dehesh K, Lindqvist Y, J Biol Chem. 1999 Mar 5;274(10):6031-4. PMID:10037680

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