1b3q

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{{STRUCTURE_1b3q| PDB=1b3q | SCENE= }}
{{STRUCTURE_1b3q| PDB=1b3q | SCENE= }}
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'''CRYSTAL STRUCTURE OF CHEA-289, A SIGNAL TRANSDUCING HISTIDINE KINASE'''
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===CRYSTAL STRUCTURE OF CHEA-289, A SIGNAL TRANSDUCING HISTIDINE KINASE===
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==Overview==
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Histidine kinases allow bacteria, plants, and fungi to sense and respond to their environment. The 2.6 A resolution crystal structure of Thermotoga maritima CheA (290-671) histidine kinase reveals a dimer where the functions of dimerization, ATP binding, and regulation are segregated into domains. The kinase domain is unlike Ser/Thr/Tyr kinases but resembles two ATPases, Gyrase B and Hsp90. Structural analogies within this superfamily suggest that the P1 domain of CheA provides the nucleophilic histidine and activating glutamate for phosphotransfer. The regulatory domain, which binds the homologous receptor-coupling protein CheW, topologically resembles two SH3 domains and provides different protein recognition surfaces at each end. The dimerization domain forms a central four-helix bundle about which the kinase and regulatory domains pivot on conserved hinges to modulate transphosphorylation. Different subunit conformations suggest that relative domain motions link receptor response to kinase activity.
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{{ABSTRACT_PUBMED_9989504}}
==About this Structure==
==About this Structure==
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[[Category: Multi-domains protein]]
[[Category: Multi-domains protein]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:01:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:10:28 2008''

Revision as of 15:10, 30 June 2008

Image:1b3q.png

Template:STRUCTURE 1b3q

CRYSTAL STRUCTURE OF CHEA-289, A SIGNAL TRANSDUCING HISTIDINE KINASE

Template:ABSTRACT PUBMED 9989504

About this Structure

1B3Q is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Structure of CheA, a signal-transducing histidine kinase., Bilwes AM, Alex LA, Crane BR, Simon MI, Cell. 1999 Jan 8;96(1):131-41. PMID:9989504

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