1b3u

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{{STRUCTURE_1b3u| PDB=1b3u | SCENE= }}
{{STRUCTURE_1b3u| PDB=1b3u | SCENE= }}
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'''CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA'''
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===CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA===
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==Overview==
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The PR65/A subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit, generating functionally diverse heterotrimers. Mutations of the beta isoform of PR65 are associated with lung and colon tumors. The crystal structure of the PR65/Aalpha subunit, at 2.3 A resolution, reveals the conformation of its 15 tandemly repeated HEAT sequences, degenerate motifs of approximately 39 amino acids present in a variety of proteins, including huntingtin and importin beta. Individual motifs are composed of a pair of antiparallel alpha helices that assemble in a mainly linear, repetitive fashion to form an elongated molecule characterized by a double layer of alpha helices. Left-handed rotations at three interrepeat interfaces generate a novel left-hand superhelical conformation. The protein interaction interface is formed from the intrarepeat turns that are aligned to form a continuous ridge.
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{{ABSTRACT_PUBMED_9989501}}
==About this Structure==
==About this Structure==
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[[Category: Pp2a]]
[[Category: Pp2a]]
[[Category: Scaffold protein]]
[[Category: Scaffold protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:01:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:11:06 2008''

Revision as of 15:11, 30 June 2008

Image:1b3u.png

Template:STRUCTURE 1b3u

CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA

Template:ABSTRACT PUBMED 9989501

About this Structure

1B3U is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs., Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D, Cell. 1999 Jan 8;96(1):99-110. PMID:9989501

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