1b6c

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[[Image:1b6c.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1b6c| PDB=1b6c | SCENE= }}
{{STRUCTURE_1b6c| PDB=1b6c | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12'''
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===CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12===
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==Overview==
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Activation of the type I TGFbeta receptor (TbetaR-I) requires phosphorylation of a regulatory segment known as the GS region, located upstream of the serine/threonine kinase domain in the cytoplasmic portion of the receptor. The crystal structure of a fragment of unphosphorylated TbetaR-I, containing both the GS region and the catalytic domain, has been determined in complex with the FK506-binding protein FKBP12. TbetaR-I adopts an inactive conformation that is maintained by the unphosphorylated GS region. FKBP12 binds to the GS region of the receptor, capping the TbetaR-II phosphorylation sites and further stabilizing the inactive conformation of TbetaR-I. Certain structural features at the catalytic center of TbetaR-I are characteristic of tyrosine kinases rather than Ser/Thr kinases.
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(as it appears on PubMed at http://www.pubmed.gov), where 10025408 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10025408}}
==About this Structure==
==About this Structure==
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[[Category: Massague, J.]]
[[Category: Massague, J.]]
[[Category: Receptor serine/threonine kinase]]
[[Category: Receptor serine/threonine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:07:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:22:11 2008''

Revision as of 15:22, 30 June 2008

Image:1b6c.png

Template:STRUCTURE 1b6c

CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12

Template:ABSTRACT PUBMED 10025408

About this Structure

1B6C is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12., Huse M, Chen YG, Massague J, Kuriyan J, Cell. 1999 Feb 5;96(3):425-36. PMID:10025408

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