1b8h

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[[Image:1b8h.gif|left|200px]]
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{{Seed}}
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[[Image:1b8h.png|left|200px]]
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{{STRUCTURE_1b8h| PDB=1b8h | SCENE= }}
{{STRUCTURE_1b8h| PDB=1b8h | SCENE= }}
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'''SLIDING CLAMP, DNA POLYMERASE'''
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===SLIDING CLAMP, DNA POLYMERASE===
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==Overview==
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We have solved the crystal structures of the bacteriophage RB69 sliding clamp, its complex with a peptide essential for DNA polymerase interactions, and the DNA polymerase complexed with primer-template DNA. The editing complex structure shows a partially melted duplex DNA exiting from the exonuclease domain at an unexpected angle and significant changes in the protein structure. The clamp complex shows the C-terminal 11 residues of polymerase bound in a hydrophobic pocket, and it allows docking of the editing and clamp structures together. The peptide binds to the sliding clamp at a position identical to that of a replication inhibitor peptide bound to PCNA, suggesting that the replication inhibitor protein p21CIP1 functions by competing with eukaryotic polymerases for the same binding pocket on the clamp.
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(as it appears on PubMed at http://www.pubmed.gov), where 10535734 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10535734}}
==About this Structure==
==About this Structure==
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[[Category: Replisome]]
[[Category: Replisome]]
[[Category: Sliding clamp]]
[[Category: Sliding clamp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:12:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:33:28 2008''

Revision as of 15:33, 30 June 2008

Image:1b8h.png

Template:STRUCTURE 1b8h

SLIDING CLAMP, DNA POLYMERASE

Template:ABSTRACT PUBMED 10535734

About this Structure

1B8H is a Protein complex structure of sequences from Enterobacteria phage rb69. Full crystallographic information is available from OCA.

Reference

Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex., Shamoo Y, Steitz TA, Cell. 1999 Oct 15;99(2):155-66. PMID:10535734

Page seeded by OCA on Mon Jun 30 18:33:28 2008

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