1b9k

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[[Image:1b9k.gif|left|200px]]
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{{STRUCTURE_1b9k| PDB=1b9k | SCENE= }}
{{STRUCTURE_1b9k| PDB=1b9k | SCENE= }}
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'''ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2'''
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===ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2===
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==Overview==
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The alpha subunit of the endocytotic AP2 adaptor complex contains a 30 kDa "appendage" domain, which is joined to the rest of the protein via a flexible linker. The 1.9 A resolution crystal structure of this domain reveals a single binding site for its ligands, which include amphiphysin, Eps15, and epsin. This domain when overexpressed in COS7 fibroblasts is shown to inhibit transferrin uptake, whereas mutants in which interactions with its binding partners are abolished do not. DPF/W motifs present in appendage domain-binding partners are shown to play a crucial role in their interactions with the domain. A single site for binding multiple ligands would allow for temporal and spatial regulation in the recruitment of components of the endocytic machinery.
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(as it appears on PubMed at http://www.pubmed.gov), where 10380931 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10380931}}
==About this Structure==
==About this Structure==
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[[Category: Adaptor]]
[[Category: Adaptor]]
[[Category: Endocytosis]]
[[Category: Endocytosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:14:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:38:15 2008''

Revision as of 15:38, 30 June 2008

Image:1b9k.png

Template:STRUCTURE 1b9k

ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2

Template:ABSTRACT PUBMED 10380931

About this Structure

1B9K is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain., Owen DJ, Vallis Y, Noble ME, Hunter JB, Dafforn TR, Evans PR, McMahon HT, Cell. 1999 Jun 11;97(6):805-15. PMID:10380931

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