1ba3

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{{STRUCTURE_1ba3| PDB=1ba3 | SCENE= }}
{{STRUCTURE_1ba3| PDB=1ba3 | SCENE= }}
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'''FIREFLY LUCIFERASE IN COMPLEX WITH BROMOFORM'''
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===FIREFLY LUCIFERASE IN COMPLEX WITH BROMOFORM===
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==Overview==
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The firefly luciferase enzyme from Photinus pyralis is probably the best-characterized model system for studying anesthetic-protein interactions. It binds a diverse range of general anesthetics over a large potency range, displays a sensitivity to anesthetics that is very similar to that found in animals, and has an anesthetic sensitivity that can be modulated by one of its substrates (ATP). In this paper we describe the properties of bromoform acting as a general anesthetic (in Rana temporaria tadpoles) and as an inhibitor of the firefly luciferase enzyme at high and low ATP concentrations. In addition, we describe the crystal structure of the low-ATP form of the luciferase enzyme in the presence of bromoform at 2.2-A resolution. These results provide a structural basis for understanding the anesthetic inhibition of the enzyme, as well as an explanation for the ATP modulation of its anesthetic sensitivity.
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(as it appears on PubMed at http://www.pubmed.gov), where 9788915 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9788915}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Photoprotein]]
[[Category: Photoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:40:36 2008''

Revision as of 15:40, 30 June 2008

Image:1ba3.png

Template:STRUCTURE 1ba3

FIREFLY LUCIFERASE IN COMPLEX WITH BROMOFORM

Template:ABSTRACT PUBMED 9788915

About this Structure

1BA3 is a Single protein structure of sequence from Photinus pyralis. Full crystallographic information is available from OCA.

Reference

Structural basis for the inhibition of firefly luciferase by a general anesthetic., Franks NP, Jenkins A, Conti E, Lieb WR, Brick P, Biophys J. 1998 Nov;75(5):2205-11. PMID:9788915

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