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1bcd

From Proteopedia

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{{STRUCTURE_1bcd| PDB=1bcd | SCENE= }}
{{STRUCTURE_1bcd| PDB=1bcd | SCENE= }}
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'''X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE'''
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===X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE===
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==Overview==
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It has recently been shown that aliphatic sulphonamides are good inhibitors of carbonic anhydrase (CA) provided that the pK of the sulphonamide is low. We have determined the structure of the complex between CAII and CF3SO2NH2 by X-ray crystallographic methods. The nitrogen of the sulphonamide is bound to the zinc ion of the enzyme in the usual manner. The other parts of the inhibitor show a different mode of binding from aromatic sulphonamides since the trifluoromethyl group is bound at the hydrophobic part of the active site instead of pointing out from the active site. It should be possible to design new inhibitors specific for the different isoenzymes, starting from the present structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_8070585}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8070585 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8070585}}
==About this Structure==
==About this Structure==
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[[Category: Hakansson, K.]]
[[Category: Hakansson, K.]]
[[Category: Liljas, A.]]
[[Category: Liljas, A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:20:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:49:22 2008''

Revision as of 15:49, 30 June 2008

Image:1bcd.png

Template:STRUCTURE 1bcd

X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE

Template:ABSTRACT PUBMED 8070585

About this Structure

1BCD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide., Hakansson K, Liljas A, FEBS Lett. 1994 Aug 22;350(2-3):319-22. PMID:8070585

Page seeded by OCA on Mon Jun 30 18:49:22 2008

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