1bcf

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{{STRUCTURE_1bcf| PDB=1bcf | SCENE= }}
{{STRUCTURE_1bcf| PDB=1bcf | SCENE= }}
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'''THE STRUCTURE OF A UNIQUE, TWO-FOLD SYMMETRIC, HAEM-BINDING SITE'''
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===THE STRUCTURE OF A UNIQUE, TWO-FOLD SYMMETRIC, HAEM-BINDING SITE===
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==Overview==
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Bacterioferritin of Escherichia coli, also known as cytochrome b1, is a hollow, nearly spherical shell made up of 24 identical protein subunits and 12 haems. We have solved this structure in a tetragonal crystal form at 2.9 A resolution. We find that each haem is bound in a pocket formed by the interface between a pair of symmetry-related subunits. The quasi-twofold axis of the haem is closely aligned with the local twofold axis relating these subunits. The axial ligands of the haem are sulphurs of two equivalent methionyl residues (Met 52) from the symmetry-related subunits. A cluster of four water molecules is trapped in the gap between the upper edge of the haem and two extended protein loops which close off the haem from the outer aqueous environment. This is the first structure of a bis-methionine ligated haem-binding site and the first case of a twofold symmetric haem-binding site.
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(as it appears on PubMed at http://www.pubmed.gov), where 7664064 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7664064}}
==About this Structure==
==About this Structure==
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[[Category: Yariv, J.]]
[[Category: Yariv, J.]]
[[Category: Iron storage and electron transport]]
[[Category: Iron storage and electron transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:20:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:49:27 2008''

Revision as of 15:49, 30 June 2008

Image:1bcf.png

Template:STRUCTURE 1bcf

THE STRUCTURE OF A UNIQUE, TWO-FOLD SYMMETRIC, HAEM-BINDING SITE

Template:ABSTRACT PUBMED 7664064

About this Structure

1BCF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of a unique twofold symmetric haem-binding site., Frolow F, Kalb AJ, Yariv J, Nat Struct Biol. 1994 Jul;1(7):453-60. PMID:7664064

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