1bdf

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{{Seed}}
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{{STRUCTURE_1bdf| PDB=1bdf | SCENE= }}
{{STRUCTURE_1bdf| PDB=1bdf | SCENE= }}
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'''STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE ALPHA SUBUNIT N-TERMINAL DOMAIN'''
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===STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE ALPHA SUBUNIT N-TERMINAL DOMAIN===
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==Overview==
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The 2.5 angstrom resolution x-ray crystal structure of the Escherichia coli RNA polymerase (RNAP) alpha subunit amino-terminal domain (alphaNTD), which is necessary and sufficient to dimerize and assemble the other RNAP subunits into a transcriptionally active enzyme and contains all of the sequence elements conserved among eukaryotic alpha homologs, has been determined. The alphaNTD monomer comprises two distinct, flexibly linked domains, only one of which participates in the dimer interface. In the alphaNTD dimer, a pair of helices from one monomer interact with the cognate helices of the other to form an extensive hydrophobic core. All of the determinants for interactions with the other RNAP subunits lie on one face of the alphaNTD dimer. Sequence alignments, combined with secondary-structure predictions, support proposals that a heterodimer of the eukaryotic RNAP subunits related to Saccharomyces cerevisiae Rpb3 and Rpb11 plays the role of the alphaNTD dimer in prokaryotic RNAP.
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(as it appears on PubMed at http://www.pubmed.gov), where 9657722 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9657722}}
==About this Structure==
==About this Structure==
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[[Category: Nucleotidyltransferase]]
[[Category: Nucleotidyltransferase]]
[[Category: Rnap]]
[[Category: Rnap]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:22:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:53:43 2008''

Revision as of 15:53, 30 June 2008

Image:1bdf.png

Template:STRUCTURE 1bdf

STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE ALPHA SUBUNIT N-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 9657722

About this Structure

1BDF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the Escherichia coli RNA polymerase alpha subunit amino-terminal domain., Zhang G, Darst SA, Science. 1998 Jul 10;281(5374):262-6. PMID:9657722

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