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1beo

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{{STRUCTURE_1beo| PDB=1beo | SCENE= }}
{{STRUCTURE_1beo| PDB=1beo | SCENE= }}
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'''BETA-CRYPTOGEIN'''
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===BETA-CRYPTOGEIN===
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==Overview==
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BACKGROUND: Elicitins form a novel class of plant necrotic proteins which are secreted by Phytophthora and Pythium fungi, parasites of many economically important crops. These proteins induce leaf necrosis in infected plants and elicit an incompatible hypersensitive-like reaction, leading to the development of a systemic acquired resistance against a range of fungal and bacterial plant pathogens. No crystal structures of this class of protein are available. The crystal structure determination of beta-cryptogein (CRY), secreted by Phytophthora cryptogea, was undertaken to identify structural features important for the necrotic activity of elicitins. RESULTS: The structure of CRY was determined using the multiwavelength anomalous diffraction technique and refined to 2.2 A resolution. The overall structure has a novel fold consisting of six alpha helices and a beak-like motif, whose sequence is highly conserved within the family, composed of an antiparallel two-stranded beta sheet and an omega loop. This motif is assumed to be a major recognition site for a putative receptor and/or ligand. Two other distinct binding sites seem to be correlated to the level of necrotic activity of elicitins. CONCLUSIONS: The determination of the crystal structure of a member of the elicitin family may make it possible to separate the activity that causes leaf necrosis from that inducing systemic acquired resistance to pathogens, making it feasible to engineer a non-toxic elicitin that only elicits plant defences. Such studies should aid the development of non-toxic agricultural pest control.
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The line below this paragraph, {{ABSTRACT_PUBMED_8994969}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8994969 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8994969}}
==About this Structure==
==About this Structure==
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[[Category: Plant pathogen]]
[[Category: Plant pathogen]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:59:26 2008''

Revision as of 15:59, 30 June 2008

Image:1beo.png

Template:STRUCTURE 1beo

BETA-CRYPTOGEIN

Template:ABSTRACT PUBMED 8994969

About this Structure

1BEO is a Single protein structure of sequence from Phytophthora cryptogea. Full crystallographic information is available from OCA.

Reference

Crystal structure of a fungal elicitor secreted by Phytophthora cryptogea, a member of a novel class of plant necrotic proteins., Boissy G, de La Fortelle E, Kahn R, Huet JC, Bricogne G, Pernollet JC, Brunie S, Structure. 1996 Dec 15;4(12):1429-39. PMID:8994969

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